ABSTRACT
El síndrome POEMS, acrónimo propuesto por Bardwick en 1980, es una entidad poco frecuente, caracterizada por la presencia de polineuropatía, organomegalia, endocrinopatía,gamapatía monoclonal y afección cutánea (skin). Presentamos un paciente de 60 años con polineuropatía, gamapatía monoclonal y lesión osteolítica solitaria que posteriormentedesarrolló hemangiomas glomerulares. Se destacan los aspectos más relevantesde esta entidad...
Subject(s)
Humans , Male , Middle Aged , Hemangioma , POEMS Syndrome/diagnosis , Endocrine System Diseases , PolyneuropathiesABSTRACT
La Dermatitis Atópica (DA), es una enfermedad de la piel bien definida clínicamente, con predisposición genética y decarácter crónico-recidivante, que se asocia a menudo con otros desordenes atópicos, como rinitis y asma. Numerosos factoresdel medio ambiente: aeroalergenos, alergenos de contacto, alimentos e infecciones juegan un importante rol en laaparición y mantenimiento de los síntomas. Se estudiaron 15 niños y 41 adultos, los síntomas relevantes fueron lesionesflexurales, prurito, xerosis e infecciones dérmicas y en los niños queratosis folicular. Niños: 67% se asociaron con enfermedadrespiratoria e iniciaron los síntomas junto o después de la DA. Los aeroalergenos involucrados fueron polvo decasa, dermatophagoides mezcla, polen de gramíneas, aspergillus y alternaria. Entre los alimentos: tomate, chocolate, cítricosy huevo fueron relevantes. El 27% mostró infecciones dérmicas. Adultos: 64% tenían enfermedad respiratoria. Soloel 20% inicio los síntomas respiratorios antes de los síntomas dérmicos. El total de los pacientes testificados presentaronresultados positivos para uno o mas aeroalergenos siendo los principales: dermatophagoides mezcla, polvo de casa, alternaria,aspergillus, cladosporium, pólenes de árboles mezcla, gramíneas, ambrosia, amarantáceas, chenopodiaceas, epiteliode perro, epitelio de gato. El 35% fue positivo a alimentos y el 37% mostró infecciones dérmicas. Asociación conhipersensibilidad de contacto: el 48% de esta población presentó síntomas de Dermatitis de Contacto (DC), el 80% delos mismos refirió intolerancia al níquel. Se efectuaron parches cutáneos en 12 pacientes adultos, resultando positivos en9 de ellos, lo cual representa que un 22% de la población adulta presenta hipersensibilidad de contacto.
Atopic dermatitis is a clinically well defined, chronic - intermitant, genetically predisposed skin disease, it is regularlyassociated with other allergic disorders such as asthma and rhinitis. Many environmental factors, aeroallergens, contactallergens, foods and infections are playing an important role in triggering and sustaining the disease. 15 children and41 adults were studied. Classics symptoms as: flexural dermatitis, itching, dry skin, and follicle queratoses were relevant,In children: 67% associated with respiratory disease, and started their respiratory symptoms together or right after theonset of atopic dermatitis. Aeroallergens involved were: house dust mite, Dermatophagoides mix, Aspergillus spp, grasspollen, and Alternaria. In addition these patients had sensitivity to foods allergens such as tomato, cocoa, citric fruits,and egg. 27% also showed skin infections. In adults: 64% had respiratory disease. Only 20% presents respiratory diseaseprevious to atopic dermatitis. All patients had positive to at least one of the aeroallergens tested. The most importantallergens were:Dermatophagoides mix, house dust mite, Alternaria, Aspergillus spp, Cladosporium, tree pollen, grasspollen, ragweed, amaranthus spp, chenopodium, dog dander and cat dander. 35% of the patients had positive prick teststo food allergens, and 37% of them also showed skin infections. Association with contact hipersensibility: 48% of thestudy population had symptoms of contact dermatitis, Patch Test was performed in 12 adults patients, only 9 patientsof them had positive test, which represent 22 % of the adult population with contact hipersensibility.
Subject(s)
Humans , Male , Adult , Female , Child , Allergens , Dermatitis, Atopic , Dermatitis, Contact , Patch TestsABSTRACT
The objective was to analyze the prevalence of mucocutaneous lesions in patients with systemic lupus erythematosus (SLE). During a 3-year period, we analyzed 77 patients with a diagnosis of SLE. The mucocutaneous lesions were classified into specific and non-specific. We defined skin type, sunlight exposure and photoprotection and correlated these lesions with serology and disease activity. Acute specific lesions were found in 67.5 of the patients, subacute lupus in 6.5 and chronic lesions in 26.0. The most prevalent non-specific lesions were alopecia (59.7), photosensitivity (57.1), Raynaud's syndrome (46.7), oral ulcerations (15.6) and livedo reticularis (11.7). Skin type 3 (35) and exposure to mild ultraviolet radiation (74) were seen in the majority of the patients. Appropriate sunlight protection was only used by 47 of the patients. When dermatological lesions and serology were compared, we found a significant association between malar rash, photosensitivity, livedo reticularis and alopecia with the presence of anti-Ro and Raynaud's phenomenon in patients with positive anti-Sm. The presence of malar rash, photosensitivity, Raynaud's phenomenon, diffuse alopecia and livedo reticularis was more frequent among patients with active disease. The prevalence of mucocutaneous manifestation in our population was slightly higher than data reported in other series. The presence of malar rash, diffuse alopecia, photosensitivity and livedo reticularis significantly related with the presence of anti-Ro and Raynaud's phenomenon with anti-Sm. All these lesions were more frequently seen in patients with active disease
Subject(s)
Adolescent , Humans , Male , Female , Child , Adult , Middle Aged , Antibodies, Antinuclear , Lupus Erythematosus, Systemic , Skin Diseases , Aged, 80 and over , Alopecia , Lupus Erythematosus, Systemic , Oral Ulcer , Photosensitivity Disorders , Raynaud Disease , Skin Diseases , Skin Diseases, VascularABSTRACT
La telangiectasia macularis eruptiva perstans (TMEP) es una forma de mastocitosis cutánea poco frecuente, que se manifiesta casi exclusivamente en adultos. Su diagnóstico es básicamente clínico y no se dispone hasta la actualidad de una terapéutica específica eficaz. Se presentan cuatro pacientes de sexo masculino, edad promedio de 54 años, con manifestaciones clínicas e histológicas de TMEP, en diferentes períoddos de evolución. Todos presentaron patología úlcero éptica, asociación frecuente de las mastocitosis cutáneas. Objetivo: Presentación clínica de una forma poco frecuente de mastocitosis cutánea y revisión de la bibliografía